Title |
Human mtDNA hypervariable regions, HVR I and II, hint at deep common maternal founder and subsequent maternal gene flow in Indian population groups
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Published in |
Journal of Human Genetics, October 2005
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DOI | 10.1007/s10038-005-0284-2 |
Pubmed ID | |
Authors |
Swarkar Sharma, Anjana Saha, Ekta Rai, Audesh Bhat, Ramesh Bamezai |
Abstract |
We have analysed the hypervariable regions (HVR I and II) of human mitochondrial DNA (mtDNA) in individuals from Uttar Pradesh (UP), Bihar (BI) and Punjab (PUNJ), belonging to the Indo-European linguistic group, and from South India (SI), that have their linguistic roots in Dravidian language. Our analysis revealed the presence of known and novel mutations in both hypervariable regions in the studied population groups. Median joining network analyses based on mtDNA showed extensive overlap in mtDNA lineages despite the extensive cultural and linguistic diversity. MDS plot analysis based on Fst distances suggested increased maternal genetic proximity for the studied population groups compared with other world populations. Mismatch distribution curves, respective neighbour joining trees and other statistical analyses showed that there were significant expansions. The study revealed an ancient common ancestry for the studied population groups, most probably through common founder female lineage(s), and also indicated that human migrations occurred (maybe across and within the Indian subcontinent) even after the initial phase of female migration to India. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 2 | 4% |
India | 1 | 2% |
Colombia | 1 | 2% |
United Kingdom | 1 | 2% |
United States | 1 | 2% |
Unknown | 49 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 24% |
Researcher | 10 | 18% |
Student > Master | 7 | 13% |
Professor | 5 | 9% |
Student > Doctoral Student | 4 | 7% |
Other | 12 | 22% |
Unknown | 4 | 7% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 18 | 33% |
Biochemistry, Genetics and Molecular Biology | 16 | 29% |
Medicine and Dentistry | 5 | 9% |
Unspecified | 2 | 4% |
Immunology and Microbiology | 2 | 4% |
Other | 6 | 11% |
Unknown | 6 | 11% |