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Alginate-Chitosan Hydrogels Provide a Sustained Gradient of Sphingosine-1-Phosphate for Therapeutic Angiogenesis

Overview of attention for article published in Annals of Biomedical Engineering, November 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (63rd percentile)
  • Good Attention Score compared to outputs of the same age and source (70th percentile)

Mentioned by

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4 tweeters

Citations

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11 Dimensions

Readers on

mendeley
23 Mendeley
Title
Alginate-Chitosan Hydrogels Provide a Sustained Gradient of Sphingosine-1-Phosphate for Therapeutic Angiogenesis
Published in
Annals of Biomedical Engineering, November 2016
DOI 10.1007/s10439-016-1768-2
Pubmed ID
Authors

Priscilla A. Williams, Kevin T. Campbell, Hessam Gharaviram, Justin L. Madrigal, Eduardo A. Silva

Abstract

Sphingosine-1-phosphate (S1P), a bioactive lipid, is a potent candidate for treatment of ischemic vascular disease. However, designing biomaterial systems for the controlled release of S1P to achieve therapeutic angiogenesis presents both biological and engineering challenges. Thus, the objective of this study was to design a hydrogel system that provides controlled and sustained release of S1P to establish local concentration gradients that promote neovascularization. Alginate hydrogels have been extensively studied and characterized for delivery of proangiogenic factors. We sought to explore if chitosan (0, 0.1, 0.5, or 1%) incorporation could be used as a means to control S1P release from alginate hydrogels. With increasing chitosan incorporation, hydrogels exhibited significantly denser pore structure and stiffer material properties. While 0.1 and 0.5% chitosan gels demonstrated slower respective release of S1P, release from 1% chitosan gels was similar to alginate gels alone. Furthermore, 0.5% chitosan gels induced greater sprouting and directed migration of outgrowth endothelial cells (OECs) in response to released S1P under hypoxia in vitro. Overall, this report presents a platform for a novel alginate-chitosan hydrogel of controlled composition and in situ gelation properties that can be used to control lipid release for therapeutic applications.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 26%
Student > Ph. D. Student 6 26%
Unspecified 5 22%
Student > Bachelor 3 13%
Other 1 4%
Other 2 9%
Readers by discipline Count As %
Engineering 6 26%
Unspecified 5 22%
Pharmacology, Toxicology and Pharmaceutical Science 3 13%
Chemistry 3 13%
Biochemistry, Genetics and Molecular Biology 2 9%
Other 4 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2017.
All research outputs
#6,987,878
of 13,908,689 outputs
Outputs from Annals of Biomedical Engineering
#837
of 1,412 outputs
Outputs of similar age
#137,319
of 379,008 outputs
Outputs of similar age from Annals of Biomedical Engineering
#12
of 41 outputs
Altmetric has tracked 13,908,689 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,412 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 379,008 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.