| Title |
Halogenated indoles eradicate bacterial persister cells and biofilms
|
|---|---|
| Published in |
AMB Express, December 2016
|
| DOI | 10.1186/s13568-016-0297-6 |
| Pubmed ID | |
| Authors |
Jin-Hyung Lee, Yong-Guy Kim, Giyeon Gwon, Thomas K. Wood, Jintae Lee |
| Abstract |
The emergence of antibiotic resistance has necessitated new therapeutic approaches to combat recalcitrant bacterial infections. Persister cells, often found in biofilms, are metabolically dormant, and thus, are highly tolerant to all traditional antibiotics and represent a major drug resistance mechanism. In the present study, 36 diverse indole derivatives were investigated with the aim of identifying novel compounds that inhibit persisters and biofilm formation by Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus. 5-Iodoindole and other halogenated indoles, 4-fluoroindole, 7-chloroindole, and 7-bromoindole, eradicated persister formation by E. coli and S. aureus, and 5-iodoindole most potently inhibited biofilm formation by the two bacteria. Unlike other antibiotics, 5-iodoindole did not induce persister cell formation, and 5-iodoindole inhibited the production of the immune-evasive carotenoid staphyloxanthin in S. aureus; hence, 5-iodoindole diminished the production of virulence factors in this strain. These results demonstrate halogenated indoles are potentially useful for controlling bacterial antibiotic resistance. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | 1% |
| Unknown | 76 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 18% |
| Student > Bachelor | 10 | 13% |
| Researcher | 9 | 12% |
| Student > Master | 9 | 12% |
| Professor > Associate Professor | 4 | 5% |
| Other | 10 | 13% |
| Unknown | 21 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 25% |
| Biochemistry, Genetics and Molecular Biology | 19 | 25% |
| Immunology and Microbiology | 5 | 6% |
| Chemical Engineering | 4 | 5% |
| Chemistry | 3 | 4% |
| Other | 6 | 8% |
| Unknown | 21 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 December 2016.
All research outputs
#15,398,970
of 22,908,162 outputs
Outputs from AMB Express
#446
of 1,236 outputs
Outputs of similar age
#250,887
of 415,991 outputs
Outputs of similar age from AMB Express
#20
of 43 outputs
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