Title |
The efficacy of alginate encapsulated CHO-K1 single chain-TRAIL producer cells in the treatment of brain tumors
|
---|---|
Published in |
Journal of Neuro-Oncology, April 2006
|
DOI | 10.1007/s11060-005-9071-3 |
Pubmed ID | |
Authors |
Jos MA Kuijlen, Bart J de Haan, Wijnand Helfrich, Jan-Freark de Boer, Douwe Samplonius, Jan Jakob A Mooij, Paul de Vos |
Abstract |
Patients with astrocytic tumors in the central nervous system (CNS) have low survival rates despite surgery and radiotherapy. Innovative therapies and strategies must be developed to prolong survival of these patients. The alginate microencapsulation method, used to continuously release a certain cytotoxic agent in the vicinity of the tumor, is such a novel therapeutic strategy. The biological functionality of the apoptosis inducing scFv425:sTRAIL protein, which was released through the microencapsulation method, was studied in vitro. Analysis of the intracerebral biocompatibility of alginate capsules was performed by implantation of empty alginate capsules in the brain of mice. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Denmark | 1 | 7% |
Unknown | 13 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 3 | 21% |
Student > Bachelor | 2 | 14% |
Student > Ph. D. Student | 2 | 14% |
Other | 1 | 7% |
Student > Doctoral Student | 1 | 7% |
Other | 3 | 21% |
Unknown | 2 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 3 | 21% |
Medicine and Dentistry | 3 | 21% |
Engineering | 2 | 14% |
Chemistry | 2 | 14% |
Immunology and Microbiology | 1 | 7% |
Other | 1 | 7% |
Unknown | 2 | 14% |