RT @killeen_gerry: @andrewflood Exactly! I like this title about schoolkids with malaria from my usual field, which captures the nature of…
@andrewflood Exactly! I like this title about schoolkids with malaria from my usual field, which captures the nature of the phenomenon nicely: https://t.co/Umgwj40XYk
Dr. Potet @julienpotet, have you or colleagues ever recorded altitude along w/ data on malaria susceptibility or severity of infection? In the past, I’ve read what affects Xanthine Oxidase, & what XO affects. Altitude affects XO. XO affects P. falcipa
RT @JohnBeachTX: @mosquito_papers @bloodSparasites Interesting study with important insights. The conclusion may leave room for a surprisi…
RT @JohnBeachTX: @mosquito_papers @bloodSparasites Interesting study with important insights. The conclusion may leave room for a surprisi…
@mosquito_papers @bloodSparasites Interesting study with important insights. The conclusion may leave room for a surprising footnote. Has anyone tested the mosquito’s ability to acquire/transmit P. falciparum while feeding on hosts that are living at high
From a different angle, I considered glaucoma & ocular pressure must be related to TRPV4 (in role of mechanical sensor.) https://t.co/nJMqxFukV2 That reminded me about elevation effect upon Xanthine oxidase & therefore upon malaria / P. falciparu
@MalariaJournal Given a comparison between P. falciparum infection rates in Gabon vs. in Kenya and Mozambique, I did a cursory check for any population or geographic traits that could be expected to affect Xanthine Oxidase XO levels. Kenya elevation, Mozam
@hanniepower @ZaminIqbal I speculate this about the mice on chronic high-fat diet: those resistant to malaria have higher serum levels of Xanthine Oxidase. Give some of them an XO inhibitor like febuxostat & malaria will be severe. https://t.co/TVqNGs
@mmw_lmw @osaka_univ_e @JExpMed Previous thread looking into altitude and malaria https://t.co/vAC5LwoqT8
@bugboyLSHTM @HTropDis From past reading, I know altitude elevates serum Xanthine Oxidase, e.g. https://t.co/ngl74QrVDL If XO truly impacts P. falciparum, then I should find studies associating altitude w/ less-severe malaria. Here: https://t.co/bmC9zqKP0