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No inflammatory gene-expression response to acute exercise in human Achilles tendinopathy

Overview of attention for article published in European Journal of Applied Physiology and Occupational Physiology, April 2013
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

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19 tweeters

Citations

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18 Dimensions

Readers on

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89 Mendeley
Title
No inflammatory gene-expression response to acute exercise in human Achilles tendinopathy
Published in
European Journal of Applied Physiology and Occupational Physiology, April 2013
DOI 10.1007/s00421-013-2638-3
Pubmed ID
Authors

Jessica Pingel, Ulrich Fredberg, Lone Ramer Mikkelsen, Peter Schjerling, Katja Maria Heinemeier, Michael Kjaer, Adrian Harisson, Henning Langberg

Abstract

Although histology data favour the view of a degenerative nature of tendinopathy, indirect support for inflammatory reactions to loading in affected tendons exists. The purpose of the present study was to elucidate whether inflammatory signalling responses after acute mechanical loading were more pronounced in tendinopathic versus healthy regions of human tendon and if treatment with non-steroidal anti-inflammatory medications (NSAID's) reduces this response. Twenty-seven tendinopathy patients (>6 months) were randomly assigned to a placebo (n = 14) or NSAID (Ibumetin NYCOMED GmbH Plant Oranienburg Germany (600 mg) × 3/day/1 week) group (n = 13) in a double-blinded-fashion. Tendon biopsies were taken from the painful and a healthy region of the same tendon 2 h after 1 h running. Gene-expression of several targets was analysed in the sampled Achilles tendon biopsies. The mRNA for TGF-β, collagen-I and collagen-III were significantly higher expressed, and decorin, CTGF, IL-6 and IL-10 were significantly lower expressed in the tendinopathic versus healthy tendon area. Only IL-10 was lower in expression in experiments with NSAID administration, while all other determined parameters were unaffected by NSAID. All ultrasonographic outcomes were unchanged in response to acute exercise and not influenced by NSAID. The signalling for collagen and TGF-beta was upregulated after acute loading in tendinopathic tendon. In contrast to the hypothesis, inflammatory signalling was not exaggerated in tendinopathic tendon 2 h after acute mechanical loading.

Twitter Demographics

The data shown below were collected from the profiles of 19 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Finland 1 1%
Denmark 1 1%
Unknown 85 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 17 19%
Student > Ph. D. Student 15 17%
Student > Doctoral Student 13 15%
Student > Bachelor 10 11%
Unspecified 8 9%
Other 26 29%
Readers by discipline Count As %
Medicine and Dentistry 40 45%
Unspecified 13 15%
Sports and Recreations 9 10%
Biochemistry, Genetics and Molecular Biology 8 9%
Nursing and Health Professions 8 9%
Other 11 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 June 2013.
All research outputs
#1,036,248
of 12,220,965 outputs
Outputs from European Journal of Applied Physiology and Occupational Physiology
#482
of 2,771 outputs
Outputs of similar age
#13,465
of 139,051 outputs
Outputs of similar age from European Journal of Applied Physiology and Occupational Physiology
#15
of 60 outputs
Altmetric has tracked 12,220,965 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,771 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.1. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 139,051 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.