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A case of true hermaphroditism reveals an unusual mechanism of twinning

Overview of attention for article published in Human Genetics, December 2006
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#3 of 2,577)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
15 news outlets
blogs
7 blogs
twitter
4 tweeters
wikipedia
1 Wikipedia page

Citations

dimensions_citation
34 Dimensions

Readers on

mendeley
60 Mendeley
connotea
1 Connotea
Title
A case of true hermaphroditism reveals an unusual mechanism of twinning
Published in
Human Genetics, December 2006
DOI 10.1007/s00439-006-0279-x
Pubmed ID
Authors

Vivienne L. Souter, Melissa A. Parisi, Dale R. Nyholt, Raj P. Kapur, Anjali K. Henders, Kent E. Opheim, Daniel F. Gunther, Michael E. Mitchell, Ian A. Glass, Grant W. Montgomery

Abstract

Traditionally twins are classified as dizygous or fraternal and monozygous or identical (Hall Twinning, 362, 2003 and 735-743). We report a rare case of 46,XX/46,XY twins: Twin A presented with ambiguous genitalia and Twin B was a phenotypically normal male. These twins demonstrate a third, previously unreported mechanism for twinning. The twins underwent initial investigation with 17-hydroxyprogesterone and testosterone levels, pelvic ultrasound and diagnostic laparoscopy. Cytogenetic analysis was performed on peripheral blood cells and skin fibroblasts. Histological examination and Fluorescence in situ hybridization studies on touch imprints were performed on gonadal biopsies. DNA analysis using more than 6,000 DNA markers was performed on skin fibroblast samples from the twins and on peripheral blood samples from both parents. Twin A was determined to be a true hermaphrodite and Twin B an apparently normal male. Both twins had a 46,XX/46,XY chromosome complement in peripheral lymphocytes, skin fibroblasts, and gonadal biopsies. The proportion of XX to XY cells varied between the twins and the tissues evaluated. Most significantly the twins shared 100% of maternal alleles and approximately 50% of paternal alleles in DNA analysis of skin fibroblasts. The twins are chimeric and share a single genetic contribution from their mother but have two genetic contributions from their father thus supporting the existence of a third, previously unreported type of twinning.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
Switzerland 1 2%
France 1 2%
Australia 1 2%
China 1 2%
United States 1 2%
Unknown 54 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 20%
Professor > Associate Professor 11 18%
Student > Ph. D. Student 8 13%
Professor 7 12%
Student > Master 6 10%
Other 16 27%
Readers by discipline Count As %
Agricultural and Biological Sciences 24 40%
Medicine and Dentistry 14 23%
Biochemistry, Genetics and Molecular Biology 8 13%
Psychology 5 8%
Unspecified 3 5%
Other 6 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 166. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2019.
All research outputs
#88,035
of 13,758,680 outputs
Outputs from Human Genetics
#3
of 2,577 outputs
Outputs of similar age
#855
of 149,176 outputs
Outputs of similar age from Human Genetics
#1
of 18 outputs
Altmetric has tracked 13,758,680 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,577 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 149,176 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.