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Long-term creatine supplementation does not significantly affect clinical markers of health in athletes

Overview of attention for article published in Molecular and Cellular Biochemistry, February 2003
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#11 of 2,447)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

news
6 news outlets
blogs
2 blogs
twitter
17 X users
facebook
4 Facebook pages
wikipedia
4 Wikipedia pages
video
51 YouTube creators

Citations

dimensions_citation
141 Dimensions

Readers on

mendeley
216 Mendeley
citeulike
1 CiteULike
Title
Long-term creatine supplementation does not significantly affect clinical markers of health in athletes
Published in
Molecular and Cellular Biochemistry, February 2003
DOI 10.1023/a:1022469320296
Pubmed ID
Authors

Richard B. Kreider, Charles Melton, Christopher J. Rasmussen, Michael Greenwood, Stacy Lancaster, Edward C. Cantler, Pervis Milnor, Anthony L. Almada

Abstract

Creatine has been reported to be an effective ergogenic aid for athletes. However, concerns have been raised regarding the long-term safety of creatine supplementation. This study examined the effects of long-term creatine supplementation on a 69-item panel of serum, whole blood, and urinary markers of clinical health status in athletes. Over a 21-month period, 98 Division IA college football players were administered in an open label manner creatine or non-creatine containing supplements following training sessions. Subjects who ingested creatine were administered 15.75 g/day of creatine monohydrate for 5 days and an average of 5 g/day thereafter in 5-10 g/day doses. Fasting blood and 24-h urine samples were collected at 0, 1, 1.5, 4, 6, 10, 12, 17, and 21 months of training. A comprehensive quantitative clinical chemistry panel was determined on serum and whole blood samples (metabolic markers, muscle and liver enzymes, electrolytes, lipid profiles, hematological markers, and lymphocytes). In addition, urine samples were quantitatively and qualitative analyzed to assess clinical status and renal function. At the end of the study, subjects were categorized into groups that did not take creatine (n = 44) and subjects who took creatine for 0-6 months (mean 4.4 +/- 1.8 months, n = 12), 7-12 months (mean 9.3 +/- 2.0 months, n = 25), and 12-21 months (mean 19.3 +/- 2.4 months, n = 17). Baseline and the subjects' final blood and urine samples were analyzed by MANOVA and 2 x 2 repeated measures ANOVA univariate tests. MANOVA revealed no significant differences (p = 0.51) among groups in the 54-item panel of quantitative blood and urine markers assessed. Univariate analysis revealed no clinically significant interactions among groups in markers of clinical status. In addition, no apparent differences were observed among groups in the 15-item panel of qualitative urine markers. Results indicate that long-term creatine supplementation (up to 21-months) does not appear to adversely effect markers of health status in athletes undergoing intense training in comparison to athletes who do not take creatine.

X Demographics

X Demographics

The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 216 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 3 1%
United Kingdom 1 <1%
Germany 1 <1%
Croatia 1 <1%
Unknown 210 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 43 20%
Student > Master 33 15%
Student > Ph. D. Student 24 11%
Researcher 15 7%
Student > Doctoral Student 10 5%
Other 34 16%
Unknown 57 26%
Readers by discipline Count As %
Sports and Recreations 45 21%
Medicine and Dentistry 41 19%
Agricultural and Biological Sciences 19 9%
Nursing and Health Professions 14 6%
Biochemistry, Genetics and Molecular Biology 8 4%
Other 23 11%
Unknown 66 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 90. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2024.
All research outputs
#473,571
of 25,373,627 outputs
Outputs from Molecular and Cellular Biochemistry
#11
of 2,447 outputs
Outputs of similar age
#594
of 140,948 outputs
Outputs of similar age from Molecular and Cellular Biochemistry
#2
of 16 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,447 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 140,948 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.