This has got me thinking: @microbeminded2 previously used an ARB for immune stimulation to treat #mecfs: https://t.co/FSwo7GpOZB Part of the proposed mechanism was via the vitamin D receptor 🧵 #longcovid #postvac
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
Immunostimulation in the treatment for chronic fatigue syndrome/myalgic encephalomyelitis https://t.co/d51dgvEcZX
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
RT @chydorina: Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin…
Why do we get symptom flares? Why does treatment often trigger flares? Death of microbes causes inflammation and cytotoxin and endotoxin release. The body must deal with debris generated from dying microbes and their remains. @remissionbiome 1/n https://
@ShaneyWright ARBs might also have (helpful) immunostimulatory effects, see here: https://t.co/FSwo7GpOZB (My experience of statins is nothing notable but dont want to stop in case they're doing something i dont realise)
RT @renesugar: Immunostimulation in the treatment for chronic fatigue syndrome/myalgic encephalomyelitis #MECFS https://t.co/WVt6VXo1GM
RT @renesugar: https://t.co/WVt6VXo1GM "olmesartan medoxomil stimulates the expression of the many endogenous antimicrobials under VDR con…
(urea also a bit low in both measures, assuming low protein diet) No signs of current infection, and as above, my general post-vax symptoms are "good" maybe immunostimulation is helping me: https://t.co/P2qz9Cp364 but no idea why it's happening (PCR yest
@RachelStrohm Absolutely fascinating journey, thanks so much for sharing! Along similar lines, some people seem to improve on angiotensin receptor blockers, with some ideas being that ARBs *stimulate* the immune system https://t.co/P2qz9Cp364
@Helma_science @patatatspeciaal Auch super spannend: https://t.co/E8NhzaezNN
https://t.co/WVt6VXo1GM "Olmesartan also has a secondary effect on immune activity. By inhibiting the ability of Angiotensin II to bind to its receptor, olmesartan reduces expression of nuclear kappa factor B (NF-kb) and the inflammatory cytokine producti
https://t.co/WVt6VXo1GM "Thus, physicians using the therapy have generally been able to prescribe olmesartan to these guidelines without patients suffering from morbid hypotension."
https://t.co/WVt6VXo1GM "The maximum pressure effect is only 12 mmHg on the systolic and 8 mmHg on the diastolic. This is easily managed by most of our cohort."
https://t.co/WVt6VXo1GM "We have found 40 mg olmesartan administered every 4–8 h to be optimally effective. Fortunately, according to the FDA, olmesartan’s antihypertensive actions begin to plateau after a single 20 mg daily dose."
https://t.co/WVt6VXo1GM "because the VDR has a short half-life (2–8 h) before it is broken apart by protease activity, our immunostimulative therapy requires that olmesartan be dosed more frequently in order to maintain VDR expression between doses."
https://t.co/WVt6VXo1GM "olmesartan medoxomil stimulates the expression of the many endogenous antimicrobials under VDR control and helps to gradually restore the activity of other nuclear receptors, which may have been impacted by VDR dysregulation."
https://t.co/WVt6VXo1GM "Central to the treatment is the use of olmesartan medoxomil. While this drug was approved as an angiotensin II receptor agonist (ARB), we showed that it also has a high affinity for the VDR nuclear receptor, for which it is most l
Immunostimulation in the treatment for chronic fatigue syndrome/myalgic encephalomyelitis #MECFS https://t.co/WVt6VXo1GM
RT @angryhacademic: Super interesting paper from @microbeminded2 et al: immunostimulation (with olmesartan - a blood pressure medication ac…
RT @angryhacademic: Super interesting paper from @microbeminded2 et al: immunostimulation (with olmesartan - a blood pressure medication ac…
Super interesting paper from @microbeminded2 et al: immunostimulation (with olmesartan - a blood pressure medication acting via blocking angiotensin receptors) to treat #MECFS https://t.co/SZ7UoOomUL #MyalgicEncephalomyelitis
@cstroeckw I haven't but it seems an interesting med as it has other immunomodulating qualities alongside it's anti-hypertensive effect. For example this paper by Amy Proal et al: https://t.co/evPp2tWvbp And this one: https://t.co/O0YsN0EOIq
@sublimepilgrim @ShaneyWright @angryhacademic By the way, olmesartan may be very interesting from the persistence viremia / dysbiosis angle as well: https://t.co/8HbxWs55ZV, although seems to need a higher dose.
@usabilityliz @exceedhergrasp1 Here’s a case series on use of the Marshall Protocol in ME/CFS published in Immunological Research: https://t.co/sdc3p82hzV. Perhaps point people to that instead of an outdated website link?
@JosGilbertoMon1 @pausedME @CyruxiME @longcovidadvoc1 @polybioRF @doctormom63 @DrEReinhold @DrMaureenHanson @BhupeshPrusty @OpenMedF @OxMEDiscovery 3/ Also here is a case series we published in Immunologic Research on the treatment colloquially called the
@inuoinmusicPho @exceedhergrasp1 Hey! I think treating the infections is key. As I think you know, we developed a treatment used by some ME/CFS patients (link below) that additionally uses a VDR agonist. But I don’t know if that is necessary for all cases:
RT @microbeminded2: @consent_patient Hey of course! Our two papers on ME/CFS thus far are: https://t.co/cac5BjsaGF and https://t.co/mYSKNSp…
@consent_patient Hey of course! Our two papers on ME/CFS thus far are: https://t.co/cac5BjsaGF and https://t.co/mYSKNSpa3d
@Scubatropin @williams_madd @jenbrea @DrEReinhold @trevmar Matt hey! Thanks for your interest in the MP. We published this paper in use of the treatment in ME/CFS: https://t.co/mYSKNSpa3d
@Dr_M_Guthridge @AnilvanderZee To get the full picture you need to pull together 100s of studies on ME/CFS associated pathogens/current microbiome research etc etc. That’s what I did in the Frontiers paper that will hopefully be published soon. Until then
RT @Hervorrager: All chronic #diseases have to go through this stupid #psychologization Many #psychiatrists & #psychologists have so much #…
RT @microbeminded2: @Dr_M_Guthridge Yes! Below are paragraphs I wrote in this 2013 paper on ME. They explain how many diseases previously t…
RT @microbeminded2: @Dr_M_Guthridge Yes! Below are paragraphs I wrote in this 2013 paper on ME. They explain how many diseases previously t…
RT @microbeminded2: @Dr_M_Guthridge Yes! Below are paragraphs I wrote in this 2013 paper on ME. They explain how many diseases previously t…
RT @microbeminded2: @Dr_M_Guthridge Yes! Below are paragraphs I wrote in this 2013 paper on ME. They explain how many diseases previously t…
RT @microbeminded2: @Dr_M_Guthridge Yes! Below are paragraphs I wrote in this 2013 paper on ME. They explain how many diseases previously t…
All chronic #diseases have to go through this stupid #psychologization Many #psychiatrists & #psychologists have so much #fantasy They should write fairy tales instead of delivering an expert opinion Modern #medicine should rely on #biomedical #facts n
RT @microbeminded2: @Dr_M_Guthridge Yes! Below are paragraphs I wrote in this 2013 paper on ME. They explain how many diseases previously t…
RT @microbeminded2: @Dr_M_Guthridge Yes! Below are paragraphs I wrote in this 2013 paper on ME. They explain how many diseases previously t…
@Dr_M_Guthridge Yes! Below are paragraphs I wrote in this 2013 paper on ME. They explain how many diseases previously tied to psychosomatic factors are now connected to #microbiome dysbiois/chronic infection: https://t.co/mYSKNSpa3d https://t.co/9Ewdq2nXF0
RT @microbeminded2: @brianvastag You cld start w/ my own papers:) Read the paper in my "pinned tweet." Also this one: https://t.co/mYSKNSpa…
@brianvastag You cld start w/ my own papers:) Read the paper in my "pinned tweet." Also this one: https://t.co/mYSKNSpa3d
@petermsullivan9 Or if you prefer a detailed paper, here is one of many https://t.co/l1lsH9mLdL
RT @scotallonme: Immunostimulation in the treatment for chronic fatigue syndrome/myalgic encephalomyelitis - Online F http://t.co/8ajEQujeBW
Immunostimulation in the treatment for chronic fatigue syndrome/myalgic encephalomyelitis - Online F http://t.co/8ajEQujeBW
Thx @Prohealth: Immunostimulation in the treatment for chronic fatigue syndrome/ME #mecfs #fibro #cfs #Spoonie http://t.co/JIaruYnJQm
Immunostimulation in the treatment for <b>chronic fatigue syndrome</b> <b>...</b>: Immunol… http://t.co/rOhQ4prMAb
RT @ME_forME: Immunostimulation in the treatment for chronic fatigue syndrome/myalgic encephalomyelitis - http://t.co/5Zfpw3yisz
RT @ME_forME: Immunostimulation in the treatment for chronic fatigue syndrome/myalgic encephalomyelitis - http://t.co/5Zfpw3yisz
RT @ME_forME: Immunostimulation in the treatment for chronic fatigue syndrome/myalgic encephalomyelitis - http://t.co/5Zfpw3yisz
Immunostimulation in the treatment for chronic fatigue syndrome/myalgic encephalomyelitis - http://t.co/5Zfpw3yisz
Immunostimulation in the treatment for chronic fatigue syndrome/myalgic encephalomyelitis. http://t.co/thuNuRySw5 #mecfs #pleaseRT
Immunostimulation in the treatment for chronic fatigue syndrome/myalgic encephalomyelitis. http://t.co/thuNuRySw5 #mecfs #pleaseRT
Immunostimulation in the treatment for chronic fatigue syndrome/myalgic encephalomyelitis. http://t.co/ZvKBCcSQdM #mecfs #pleaseRT
Immunostimulation in the treatment for chronic fatigue syndrome/myalgic encephalomyelitis. http://t.co/thuNuRySw5 #mecfs #pleaseRT
IMMUNOSTIMULATION in the treatment for #CFS / #ME #MECFS #VDR dysregulation http://t.co/pCbtlZx21K
Immunostimulation in the treatment for chronic fatigue syndrome/myalgic encephalomyelitis #MECFS #VDR http://t.co/pCbtlZx21K
Immunostimulation in the treatment for chronic fatigue syndrome/myalgic encephalomyelitis #mecfs #cfs #fibro #spoonie http://t.co/yW2rBFgd7W
Immunostimulation in the treatment for chronic fatigue syndrome/myalgic encephalomyelitis. Chronic infection... http://t.co/aNRZ3Wc6h6
RT @TomKindlon: "Immunostimulation in the treatment for #CFS/#ME" (Proal et al. incl Trevor Marshall, 2013) http://t.co/nmoI2JS7vC #MECFS #Spoonie #Spoonies
"Immunostimulation in the treatment for #CFS/#ME" (Proal et al. incl Trevor Marshall, 2013) http://t.co/nmoI2JS7vC #MECFS #Spoonie #Spoonies