Title |
α-Synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers
|
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Published in |
Acta Neuropathologica, July 2006
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DOI | 10.1007/s00401-006-0104-6 |
Pubmed ID | |
Authors |
Katrin Beyer |
Abstract |
Alpha-synuclein aggregation is thought to be a key event in the pathogenesis of synucleinopathies. Although different alpha-synuclein alterations and modifications have been proposed to be responsible for early aggregation steps, the mechanisms underlying these events remain unclarified. Alpha-synuclein is a small protein localized to synaptic terminals and its intrinsic structure has been claimed to be an important factor for self-oligomerization and self-aggregation. Alpha-synuclein expression studies in cell cultures have demonstrated that posttranslational modifications, such as phosphorylation, oxidation, and sumoylation, are primarily involved in alpha-synuclein aggregation. Furthermore, in the last few years accumulating evidence has pointed to alternative splicing as a crucial mechanism in the development of neurodegenerative disorders. At least three different alpha-synuclein isoforms have been described as products of alternative splicing. Two of these isoforms (alpha-synuclein 112 and alpha-synuclein 126) are shorter proteins with probably altered functions and aggregation propensity. The present review attempts to summarize the data so far available on alpha-synuclein structure, posttranslational modifications, and alternative splicing as possible enhancers of aggregation. |
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United Kingdom | 3 | 1% |
India | 2 | <1% |
Netherlands | 1 | <1% |
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Argentina | 1 | <1% |
Denmark | 1 | <1% |
United States | 1 | <1% |
Unknown | 260 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
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Student > Master | 42 | 15% |
Researcher | 39 | 14% |
Student > Bachelor | 33 | 12% |
Student > Doctoral Student | 10 | 4% |
Other | 41 | 15% |
Unknown | 56 | 21% |
Readers by discipline | Count | As % |
---|---|---|
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Biochemistry, Genetics and Molecular Biology | 44 | 16% |
Chemistry | 26 | 10% |
Medicine and Dentistry | 26 | 10% |
Neuroscience | 22 | 8% |
Other | 22 | 8% |
Unknown | 64 | 23% |