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The Influence of Fluorine on the Disturbances of Homeostasis in the Central Nervous System

Overview of attention for article published in Biological Trace Element Research, October 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#25 of 1,237)
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

twitter
27 tweeters
facebook
9 Facebook pages

Citations

dimensions_citation
25 Dimensions

Readers on

mendeley
46 Mendeley
Title
The Influence of Fluorine on the Disturbances of Homeostasis in the Central Nervous System
Published in
Biological Trace Element Research, October 2016
DOI 10.1007/s12011-016-0871-4
Pubmed ID
Authors

K. Dec, A. Łukomska, D. Maciejewska, K. Jakubczyk, I. Baranowska-Bosiacka, D. Chlubek, A. Wąsik, I. Gutowska

Abstract

Fluorides occur naturally in the environment, the daily exposure of human organism to fluorine mainly depends on the intake of this element with drinking water and it is connected with the geographical region. In some countries, we can observe the endemic fluorosis-the damage of hard and soft tissues caused by the excessive intake of fluorine. Recent studies showed that fluorine is toxic to the central nervous system (CNS). There are several known mechanisms which lead to structural brain damage caused by the excessive intake of fluorine. This element is able to cross the blood-brain barrier, and it accumulates in neurons affecting cytological changes, cell activity and ion transport (e.g. chlorine transport). Additionally, fluorine changes the concentration of non-enzymatic advanced glycation end products (AGEs), the metabolism of neurotransmitters (influencing mainly glutamatergic neurotransmission) and the energy metabolism of neurons by the impaired glucose transporter-GLUT1. It can also change activity and lead to dysfunction of important proteins which are part of the respiratory chain. Fluorine also affects oxidative stress, glial activation and inflammation in the CNS which leads to neurodegeneration. All of those changes lead to abnormal cell differentiation and the activation of apoptosis through the changes in the expression of neural cell adhesion molecules (NCAM), glial fibrillary acidic protein (GFAP), brain-derived neurotrophic factor (BDNF) and MAP kinases. Excessive exposure to this element can cause harmful effects such as permanent damage of all brain structures, impaired learning ability, memory dysfunction and behavioural problems. This paper provides an overview of the fluoride neurotoxicity in juveniles and adults.

Twitter Demographics

The data shown below were collected from the profiles of 27 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 46 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 20%
Student > Master 7 15%
Unspecified 6 13%
Student > Doctoral Student 5 11%
Student > Ph. D. Student 5 11%
Other 14 30%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 22%
Unspecified 9 20%
Medicine and Dentistry 8 17%
Environmental Science 5 11%
Pharmacology, Toxicology and Pharmaceutical Science 3 7%
Other 11 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2019.
All research outputs
#747,531
of 13,396,110 outputs
Outputs from Biological Trace Element Research
#25
of 1,237 outputs
Outputs of similar age
#27,009
of 286,799 outputs
Outputs of similar age from Biological Trace Element Research
#1
of 27 outputs
Altmetric has tracked 13,396,110 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,237 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,799 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.