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Nuclear reformation after mitosis requires downregulation of the Ran GTPase effector RanBP1 in mammalian cells

Overview of attention for article published in Chromosoma, July 2010
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Title
Nuclear reformation after mitosis requires downregulation of the Ran GTPase effector RanBP1 in mammalian cells
Published in
Chromosoma, July 2010
DOI 10.1007/s00412-010-0286-5
Pubmed ID
Authors

Marilena Ciciarello, Emanuele Roscioli, Barbara Di Fiore, Laura Di Francesco, Fabrizia Sobrero, Delphine Bernard, Rosamaria Mangiacasale, Amnon Harel, Maria Eugenia Schininà, Patrizia Lavia

Abstract

The GTPase Ran regulates nucleocytoplasmic transport in interphase and spindle organisation in mitosis via effectors of the importin beta superfamily. Ran-binding protein 1 (RanBP1) regulates guanine nucleotide turnover on Ran, as well as its interactions with effectors. Unlike other Ran network members that are steadily expressed, RanBP1 abundance is modulated during the mammalian cell cycle, peaking in mitosis and declining at mitotic exit. Here, we show that RanBP1 downregulation takes place in mid to late telophase, concomitant with the reformation of nuclei. Mild RanBP1 overexpression in murine cells causes RanBP1 to persist in late mitosis and hinders a set of events underlying the telophase to interphase transition, including chromatin decondensation, nuclear expansion and nuclear lamina reorganisation. Moreover, the reorganisation of nuclear pores fails associated with defective nuclear relocalisation of NLS cargoes. Co-expression of importin beta, together with RanBP1, however mitigates these defects. Thus, RanBP1 downregulation is required for nuclear reorganisation pathways operated by importin beta after mitosis.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 5%
Japan 1 5%
Czechia 1 5%
Canada 1 5%
Unknown 15 79%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 37%
Researcher 6 32%
Professor 2 11%
Student > Doctoral Student 2 11%
Student > Bachelor 1 5%
Other 1 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 63%
Biochemistry, Genetics and Molecular Biology 4 21%
Neuroscience 3 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 December 2010.
All research outputs
#10,833,312
of 12,220,306 outputs
Outputs from Chromosoma
#536
of 587 outputs
Outputs of similar age
#115,653
of 138,811 outputs
Outputs of similar age from Chromosoma
#3
of 4 outputs
Altmetric has tracked 12,220,306 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 587 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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