| Title |
Elevated prefrontal myo-inositol and choline following breast cancer chemotherapy
|
|---|---|
| Published in |
Brain Imaging and Behavior, March 2013
|
| DOI | 10.1007/s11682-013-9228-1 |
| Pubmed ID | |
| Authors |
Shelli R. Kesler, Christa Watson, Della Koovakkattu, Clement Lee, Ruth O’Hara, Misty L. Mahaffey, Jeffrey S. Wefel |
| Abstract |
Breast cancer survivors are at increased risk for cognitive dysfunction, which reduces quality of life. Neuroimaging studies provide critical insights regarding the mechanisms underlying these cognitive deficits as well as potential biologic targets for interventions. We measured several metabolite concentrations using (1)H magnetic resonance spectroscopy as well as cognitive performance in 19 female breast cancer survivors and 17 age-matched female controls. Women with breast cancer were all treated with chemotherapy. Results indicated significantly increased choline (Cho) and myo-inositol (mI) with correspondingly decreased N-acetylaspartate (NAA)/Cho and NAA/mI ratios in the breast cancer group compared to controls. The breast cancer group reported reduced executive function and memory, and subjective memory ability was correlated with mI and Cho levels in both groups. These findings provide preliminary evidence of an altered metabolic profile that increases our understanding of neurobiologic status post-breast cancer and chemotherapy. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 115 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Russia | 1 | <1% |
| Unknown | 113 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 19 | 17% |
| Student > Ph. D. Student | 16 | 14% |
| Researcher | 12 | 10% |
| Student > Bachelor | 11 | 10% |
| Other | 8 | 7% |
| Other | 19 | 17% |
| Unknown | 30 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 25 | 22% |
| Medicine and Dentistry | 17 | 15% |
| Neuroscience | 9 | 8% |
| Nursing and Health Professions | 8 | 7% |
| Biochemistry, Genetics and Molecular Biology | 8 | 7% |
| Other | 13 | 11% |
| Unknown | 35 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2014.
All research outputs
#14,165,787
of 22,703,044 outputs
Outputs from Brain Imaging and Behavior
#558
of 1,151 outputs
Outputs of similar age
#112,839
of 197,824 outputs
Outputs of similar age from Brain Imaging and Behavior
#6
of 11 outputs
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