↓ Skip to main content

Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated from Kaziranga National Park, Assam, India

Overview of attention for article published in SpringerPlus, March 2013
Altmetric Badge

Mentioned by

facebook
1 Facebook page

Citations

dimensions_citation
15 Dimensions

Readers on

mendeley
27 Mendeley
Title
Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated from Kaziranga National Park, Assam, India
Published in
SpringerPlus, March 2013
DOI 10.1186/2193-1801-2-122
Pubmed ID
Authors

C Ganesh Kumar, Poornima Mongolla, Pombala Sujitha, Joveeta Joseph, K Suresh Babu, Gangi Suresh, Kallaganti Venkata Siva Ramakrishna, Uppula Purushotham, G Narahari Sastry, Ahmed Kamal

Abstract

In an ongoing survey for bioactive potential of microorganisms from different biosphere zones of India, a new Chrysosporium lobatum strain BK-3 was isolated from soil sample collected from a biodiversity hotspot, Kaziranga National Park, Assam, India. Bioactivity-guided purification resulted in the isolation of two bioactive compounds whose chemical structures were elucidated by (1)H and (13)C Nuclear Magnetic Resonance (NMR), 2D-NMR, Fourier Transform Infra-red (FT-IR) and mass spectroscopic techniques, and were identified as α, β-dehydrocurvularin and curvularin. Only curvularin exhibited 80% acetylcholinesterase (AChE) inhibitory activity. Detailed ligand receptor binding interactions were studied for curvularin by molecular docking studies. Further, both curvularin and α, β-dehydrocurvularin had similar level of cytotoxicity against different human tumour cell lines like A549, HeLa, MDA-MB-231 and MCF-7, while α, β-dehydrocurvularin was active against COLO 205 with a IC50 of 7.9 μM, but curvularin was inactive. α, β-Dehydrocurvularin also showed good superoxide anion scavenging activity with an EC50 value of 16.71 μg ml(-1). Hence, both these compounds exhibited differences in bioactive profiles and this was probably associated with their minor structural differences. This is a first report on bioactive compounds exhibiting AChE inhibitory, cytotoxicity and antioxidant activities from Chrysosporium lobatum strain BK-3.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Algeria 1 4%
India 1 4%
Unknown 25 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 26%
Researcher 6 22%
Student > Master 3 11%
Student > Bachelor 2 7%
Professor 1 4%
Other 3 11%
Unknown 5 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 41%
Medicine and Dentistry 2 7%
Biochemistry, Genetics and Molecular Biology 2 7%
Veterinary Science and Veterinary Medicine 1 4%
Environmental Science 1 4%
Other 2 7%
Unknown 8 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2013.
All research outputs
#20,185,720
of 22,701,287 outputs
Outputs from SpringerPlus
#1,461
of 1,852 outputs
Outputs of similar age
#172,773
of 197,559 outputs
Outputs of similar age from SpringerPlus
#68
of 135 outputs
Altmetric has tracked 22,701,287 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,852 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,559 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 135 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.