| Title |
Epigenetic Factors and Autism Spectrum Disorders
|
|---|---|
| Published in |
NeuroMolecular Medicine, March 2013
|
| DOI | 10.1007/s12017-013-8222-5 |
| Pubmed ID | |
| Authors |
Bess M. Flashner, Mark E. Russo, Jenine E. Boileau, Derek W. Leong, G. Ian Gallicano |
| Abstract |
Autism is a complex neurodevelopmental disorder that has significant phenotypic overlap with several diseases, many of which fall within the broader category of autism spectrum disorders (ASDs). The etiology of the disorder is unclear and seems to involve a complex interplay of polygenic as well as environmental factors. We discuss evidence that suggests that epigenetic dysregulation is highly implicated as a contributing cause of ASDs and autism. Specifically, we examine neurodevelopmental disorders that share significant phenotypic overlap with ASDs and feature the dysregulation of epigenetically modified genes including UBE3A, GABA receptor genes, and RELN. We then look at the dysregulated expression of implicated epigenetic modifiers, namely MeCP2, that yield complex and varied downstream pleiotropic effects. Finally, we examine epigenetically mediated parent-of-origin effects through which paternal gene expression dominates that of maternal contributing to contrasting phenotypes implicated in ASDs. Such preliminary evidence suggests that elucidating the complex role of epigenetic regulations involved in ASDs could prove vital in furthering our understanding of the complex etiology of autism and ASDs. |
Mendeley readers
The data shown below were compiled from readership statistics for 144 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Chile | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 141 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 25 | 17% |
| Student > Bachelor | 20 | 14% |
| Researcher | 16 | 11% |
| Student > Ph. D. Student | 16 | 11% |
| Student > Doctoral Student | 9 | 6% |
| Other | 25 | 17% |
| Unknown | 33 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 24 | 17% |
| Psychology | 22 | 15% |
| Agricultural and Biological Sciences | 19 | 13% |
| Biochemistry, Genetics and Molecular Biology | 16 | 11% |
| Neuroscience | 15 | 10% |
| Other | 14 | 10% |
| Unknown | 34 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2023.
All research outputs
#4,905,452
of 25,654,806 outputs
Outputs from NeuroMolecular Medicine
#115
of 482 outputs
Outputs of similar age
#38,760
of 208,338 outputs
Outputs of similar age from NeuroMolecular Medicine
#5
of 7 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 482 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 208,338 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.