Leptin also ⬆️ lung expression of suppressor of cytokine signalling (SOCS)-3, which suppresses IFN signalling ⬆️SOCS-3 has been reported in PBMCs from obese individuals, which had ⬇️ type I IFN following TLR-agonist stimulation https://t.co/miu4apVt05 /1
@times_funky Sorry it was not a literal question, although if you had more supporting papers that would be great. https://t.co/89YwhTIHsZ https://t.co/oC0OGsNPp8
@SteveBigpond @RA05h09mDec45 @Raque1le @NickHudsonCT As SARS2 has several tricks to suppress type I/III IFN signaling, leptin’s similar role is likely important, too. https://t.co/6widCQhZxs On the other hand, this is a bidirectional interaction. https://t
@herbersh Hyperleptinemia https://t.co/oC0OGsNPp8
RT @MichaelAlbertMD: Patients with obesity have dysregulated type 1 interferon response to viral infections. It likely explains at least so…
Patients with obesity have dysregulated type 1 interferon response to viral infections. It likely explains at least some part of the increased risk for severe #COVID19. https://t.co/to56OTaUET
Role of Leptin and SOCS3 in Inhibiting the Type I Interferon Response During Obesity https://t.co/xm3gjdKQNH #springerlink