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High Levels of Inflammation and Insulin Resistance in Obstructive Sleep Apnea Patients with Hypertension

Overview of attention for article published in Inflammation, April 2012
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Title
High Levels of Inflammation and Insulin Resistance in Obstructive Sleep Apnea Patients with Hypertension
Published in
Inflammation, April 2012
DOI 10.1007/s10753-012-9464-3
Pubmed ID
Authors

Xiaoshun Qian, Tong Yin, Tianzhi Li, Chunyan Kang, Ruibiao Guo, Baojun Sun, Changting Liu

Abstract

Hypertension induced by obstructive sleep apnea (OSA) may be multifactorial in origin, and systemic inflammation is one of the major factors. However, OSA patients do not always have the identical probability with hypertension even in patients with the same history and degree of OSA. The aim of this study was to compare the levels of inflammation and insulin resistance in two groups of patients who had the same degree as well as the same long history of OSA, but with/without hypertension. OSA patients (Apnea Hyponea Index, AHI ≥ 40/h, n = 70) were examined by polysomnography and blood analysis for the measurements of fasting plasma glucose, serum insulin (FINS), high-sensitivity C-reactive protein (CRP), peptide C,TNF-α, IL-6, and IL-10. Patients with hypertension (n = 40) had higher level of LDL-C and lower HDL-C levels than patients without hypertension. Almost half (16/40) of OSA patients with hypertension had family history of hypertension. Moreover in OSA patients with hypertension, the levels of TNF-α, IL-6, and CRP were higher, but IL-10 was lower than those without hypertension. FINS, peptide C, HOMA-IR, and HOMA-islet were also higher in OSA patients with hypertension. OSA patients with hypertension have higher level of inflammation and insulin resistance. Systemic inflammation and insulin resistance are both important factors for the development of hypertension in OSA patients.

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Mendeley readers

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The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Finland 1 3%
United States 1 3%
Unknown 33 94%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 20%
Other 5 14%
Researcher 4 11%
Student > Ph. D. Student 4 11%
Student > Master 3 9%
Other 5 14%
Unknown 7 20%
Readers by discipline Count As %
Medicine and Dentistry 16 46%
Agricultural and Biological Sciences 2 6%
Environmental Science 1 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Immunology and Microbiology 1 3%
Other 6 17%
Unknown 8 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 January 2013.
All research outputs
#20,180,477
of 22,694,633 outputs
Outputs from Inflammation
#708
of 1,045 outputs
Outputs of similar age
#146,818
of 161,974 outputs
Outputs of similar age from Inflammation
#15
of 18 outputs
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