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Is treatment for bipolar disorder more effective earlier in illness course? A comprehensive literature review

Overview of attention for article published in International Journal of Bipolar Disorders, September 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#12 of 309)
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

news
7 news outlets
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9 X users

Citations

dimensions_citation
57 Dimensions

Readers on

mendeley
130 Mendeley
Title
Is treatment for bipolar disorder more effective earlier in illness course? A comprehensive literature review
Published in
International Journal of Bipolar Disorders, September 2016
DOI 10.1186/s40345-016-0060-6
Pubmed ID
Authors

Katie Joyce, Andrew Thompson, Steven Marwaha

Abstract

We aimed to investigate a key element of the early intervention approach whether treatment at an earlier stage of bipolar disorder is more effective than later in its course. A comprehensive literature review using Medline, Embase, Psychinfo, PsycArticle, and Web of Science, as data sources, with a subsequent narrative synthesis. Study quality was assessed using the Cochrane risk of bias method. Our search strategy yielded eight primary papers and two meta-analyses (of psychological therapies and Olanzapine) in total representing 8942 patients. Five studies focused on comparisons between first and multiple episodes, and the others on fewer vs more episode categories. There was a consistent finding, suggesting treatment in earlier illness stage resulted in better outcomes in terms of response, relapse rate, time to recurrence, symptomatic recovery, remission, psychosocial functioning, and employment. This effect was found for pharmacological (Lithium, Olanzapine, Divalproex) and psychological treatments. There was high risk of selection, performance, and attrition bias in most studies. First admission or presentation is unlikely to equate to first episode, because of the duration of untreated illness. Some patients having experienced multiple episodes could be "treatment resistant". Study heterogeneity precluded meta-analysis. Psychological and pharmacological treatments in the early stages of illness are more effective than in the later stages of bipolar disorder across multiple domains. There is a first episode and the early phase effect. Consistent with the staging model of illness, findings provide evidence for the clinical utility of an early intervention approach in bipolar disorder to improve patient outcomes.

X Demographics

X Demographics

The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 130 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 <1%
Sweden 1 <1%
Unknown 128 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 19 15%
Student > Postgraduate 16 12%
Researcher 13 10%
Student > Master 12 9%
Student > Ph. D. Student 11 8%
Other 26 20%
Unknown 33 25%
Readers by discipline Count As %
Medicine and Dentistry 37 28%
Psychology 23 18%
Nursing and Health Professions 7 5%
Agricultural and Biological Sciences 4 3%
Neuroscience 4 3%
Other 16 12%
Unknown 39 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 60. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 May 2023.
All research outputs
#667,036
of 24,318,236 outputs
Outputs from International Journal of Bipolar Disorders
#12
of 309 outputs
Outputs of similar age
#13,270
of 335,549 outputs
Outputs of similar age from International Journal of Bipolar Disorders
#2
of 5 outputs
Altmetric has tracked 24,318,236 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 309 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.0. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,549 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.