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A longitudinal study of surgical outcome of pharmacoresistant epilepsy caused by focal cortical dysplasia

Overview of attention for article published in Journal of Neurology, September 2016
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Title
A longitudinal study of surgical outcome of pharmacoresistant epilepsy caused by focal cortical dysplasia
Published in
Journal of Neurology, September 2016
DOI 10.1007/s00415-016-8274-1
Pubmed ID
Authors

Bo Jin, Jing Wang, Jian Zhou, Shuang Wang, Yuguang Guan, Shuhua Chen

Abstract

This study aimed to determine the long-term surgical outcome of pharmacoresistant epilepsy caused by focal cortical dysplasia (FCD) and to identify the important predictors of the favorable surgical outcome. The study retrospectively analyzed the data of pharmacoresistant epilepsy patients with histologically proven FCD in our epilepsy center from May 2010 to December 2014. It included 120 patients with a mean follow-up of 34.6 months. Survival analysis and multivariate regression with Cox proportional hazards model were used to evaluate the rate, stability, and predictors of seizure freedom. The estimated chance of seizure freedom was 73.0 % [95 % confidence intervals (CI), 65.2-80.8 %] at 1 year after surgery, 70.0 % (95 % CI, 62.2-77.8 %) at 2 years, and 65 % (95 % CI, 53.2-76.7 %) at 5 years and beyond. Most seizure recurrences (85.7 %) happened within 12 months after surgery. The incomplete resection of FCD, presence of interictal epileptiform discharges (IEDs) on 3-6 months postoperative electroencephalography (EEG), and presence of habitual acute postoperative seizure (APOS) were independent predictors of seizure recurrence. However, other factors, such as the FCD type and sleep-related epilepsy, did not significantly influence the surgical outcome. Before becoming pharmacoresistant epilepsy, 30 (25 %) patients responded to antiepileptic drugs with a seizure-free duration of more than 1 year. The surgical outcome is favorable in patients with FCD, which is comparable to that reported in developed countries. The incomplete resection of FCD, presence of IEDs on 3-6 months postoperative EEG, and presence of habitual APOS are powerful predictive factors for seizure recurrence after surgery.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 24%
Unspecified 4 24%
Student > Postgraduate 2 12%
Researcher 2 12%
Student > Ph. D. Student 2 12%
Other 3 18%
Readers by discipline Count As %
Medicine and Dentistry 8 47%
Unspecified 5 29%
Neuroscience 3 18%
Psychology 1 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 April 2017.
All research outputs
#10,833,180
of 12,220,568 outputs
Outputs from Journal of Neurology
#2,027
of 2,306 outputs
Outputs of similar age
#218,034
of 261,692 outputs
Outputs of similar age from Journal of Neurology
#64
of 76 outputs
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