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Astrocytes and Glioblastoma cells release exosomes carrying mtDNA

Overview of attention for article published in Journal of Neural Transmission, August 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

twitter
1 tweeter
patent
2 patents

Citations

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270 Dimensions

Readers on

mendeley
282 Mendeley
Title
Astrocytes and Glioblastoma cells release exosomes carrying mtDNA
Published in
Journal of Neural Transmission, August 2009
DOI 10.1007/s00702-009-0288-8
Pubmed ID
Authors

Michele Guescini, Susanna Genedani, Vilberto Stocchi, Luigi Francesco Agnati

Abstract

Cells can exchange information not only by means of chemical and/or electrical signals, but also via microvesicles released into the intercellular space. The present paper, for the first time, provides evidence that Glioblastoma and Astrocyte cells release microvesicles, which carry mitochondrial DNA (mtDNA). These microvesicles have been characterised as exosomes in view of the presence of some protein markers of exosomes, such as Tsg101, CD9 and Alix. Thus, the important finding has been obtained that bonafide exosomes, constitutively released by Glioblastoma cells and Astrocytes, can carry mtDNA, which can be, therefore, transferred between cells. This datum may help the understanding of some diseases due to mitochondrial alterations.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 282 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 1%
Chile 2 <1%
Italy 2 <1%
Brazil 2 <1%
Japan 1 <1%
Uruguay 1 <1%
United Kingdom 1 <1%
Netherlands 1 <1%
Sweden 1 <1%
Other 0 0%
Unknown 268 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 72 26%
Researcher 61 22%
Student > Master 50 18%
Student > Bachelor 29 10%
Unspecified 13 5%
Other 57 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 115 41%
Biochemistry, Genetics and Molecular Biology 57 20%
Medicine and Dentistry 32 11%
Unspecified 22 8%
Neuroscience 19 7%
Other 37 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2015.
All research outputs
#1,942,535
of 11,917,240 outputs
Outputs from Journal of Neural Transmission
#194
of 1,149 outputs
Outputs of similar age
#56,503
of 304,169 outputs
Outputs of similar age from Journal of Neural Transmission
#1
of 17 outputs
Altmetric has tracked 11,917,240 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,149 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 304,169 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.