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Gastroprotective activity of essential oil of the Syzygium aromaticum and its major component eugenol in different animal models

Overview of attention for article published in Naunyn-Schmiedeberg's Archives of Pharmacology, December 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#35 of 1,058)
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

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1 news outlet
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9 Facebook pages

Citations

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43 Dimensions

Readers on

mendeley
48 Mendeley
Title
Gastroprotective activity of essential oil of the Syzygium aromaticum and its major component eugenol in different animal models
Published in
Naunyn-Schmiedeberg's Archives of Pharmacology, December 2010
DOI 10.1007/s00210-010-0582-x
Pubmed ID
Authors

José Roberto Santin, Marivane Lemos, Luiz Carlos Klein-Júnior, Isabel Daufenback Machado, Philipe Costa, Ana Paula de Oliveira, Crislaine Tilia, Juliana Paula de Souza, João Paulo Barreto de Sousa, Jairo Kenupp Bastos, Sérgio Faloni de Andrade

Abstract

Syzygium aromaticum, a medicinal plant commonly known as clove, is used to treat toothache, respiratory disorders, inflammation, and gastrointestinal disorders. From the flower buds of S. aromaticum, it is possible to obtain an essential oil comprised of a mixture of aliphatic and cyclic volatile terpenes and phenylpropanoids, being eugenol as the main component. The aims of this study were: (1) to extract the essential oil of the flower buds of S. aromaticum, (2) to identify and quantify the main component of the essential oil, and (3) to evaluate its antiulcer activity using different animal models. Assays were performed using the following protocols in rats: indomethacin-induced and ethanol/HCl-induced ulcer model. Both essential oils from S. aromaticum and eugenol displayed antiulcer activities in the rat models of indomethacin- and ethanol-induced ulcer. Studies focusing on the possible mechanisms of gastroprotection were also undertaken using the following experiments: evaluation of gastric secretion by the pylorus-ligated model, determination of mucus in gastric content, participation of nitric oxide (NO) and endogenous sulfhydryl in gastric protection. The results show that there was no significant effect on the volume of gastric juice and total acidity. However, the quantification of free gastric mucus showed that the clove oil and eugenol were capable of significantly enhancing mucus production. With regard to the NO and endogenous sulfhydryls, the results demonstrated that the gastroprotection induced by clove oil and eugenol are not related to the activities of the nitric oxide and endogenous sulfhydryls. No sign of toxicity was observed in the acute toxicity study. In conclusion, the results of this study show that essential oil of S. aromaticum, as well as its main component (eugenol), possesses antiulcer activity. The data suggest that the effectiveness of the essential oil and eugenol is based on its ability to stimulate the synthesis of mucus, an important gastroprotective factor. However, further pharmacological and toxicological investigations are required to enable its use for the treatment of gastric ulcer.

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 2%
China 1 2%
Unknown 46 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 19%
Student > Master 8 17%
Student > Doctoral Student 8 17%
Student > Bachelor 6 13%
Student > Ph. D. Student 5 10%
Other 12 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 31%
Pharmacology, Toxicology and Pharmaceutical Science 7 15%
Unspecified 6 13%
Biochemistry, Genetics and Molecular Biology 5 10%
Medicine and Dentistry 5 10%
Other 10 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2018.
All research outputs
#1,506,923
of 12,808,036 outputs
Outputs from Naunyn-Schmiedeberg's Archives of Pharmacology
#35
of 1,058 outputs
Outputs of similar age
#28,230
of 227,816 outputs
Outputs of similar age from Naunyn-Schmiedeberg's Archives of Pharmacology
#1
of 5 outputs
Altmetric has tracked 12,808,036 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,058 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,816 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them