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Identification of CHCHD10 Mutation in Chinese Patients with Alzheimer Disease

Overview of attention for article published in Molecular Neurobiology, August 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

news
1 news outlet
twitter
1 tweeter

Citations

dimensions_citation
7 Dimensions

Readers on

mendeley
13 Mendeley
Title
Identification of CHCHD10 Mutation in Chinese Patients with Alzheimer Disease
Published in
Molecular Neurobiology, August 2016
DOI 10.1007/s12035-016-0056-3
Pubmed ID
Authors

Xiao, Tingting, Jiao, Bin, Zhang, Weiwei, Pan, Chuzheng, Wei, Jingya, Liu, Xiaoyan, Zhou, Yafang, Zhou, Lin, Tang, Beisha, Shen, Lu

Abstract

CHCHD10 gene has been identified to be associated with frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Considering the clinical phenotype and pathology characterization were overlapped between FTD and Alzheimer disease (AD), and so far, no systematic analysis of CHCHD10 mutation was conducted in patients with AD in Asian population. Therefore, we screened of all exons in CHCHD10 in a cohort of 484 AD patients (60 with family history) from Mainland China. A heterozygous variant p.A35D (c.104C>A), previously reported in a patient with FTD in Italian population, was identified in a female patient with sporadic LOAD. The age at onset of mutation carrier was 86, presented as typical amnestic dementia. The mutation was found to be deleterious according to in silico predictions and excluded in 500 ethnically and geographically matched controls. Our finding revealed the clinical manifestations of variant p.A35D (c.104C>A) in a LOAD case and indicated that CHCHD10 mutation was presented in different types of dementia.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 31%
Researcher 3 23%
Student > Master 2 15%
Student > Postgraduate 1 8%
Other 1 8%
Other 2 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 31%
Unspecified 2 15%
Biochemistry, Genetics and Molecular Biology 2 15%
Neuroscience 2 15%
Environmental Science 1 8%
Other 2 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 September 2016.
All research outputs
#848,660
of 8,317,445 outputs
Outputs from Molecular Neurobiology
#158
of 1,450 outputs
Outputs of similar age
#39,070
of 251,840 outputs
Outputs of similar age from Molecular Neurobiology
#15
of 95 outputs
Altmetric has tracked 8,317,445 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,450 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,840 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.