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Renal and neurological side effects of colistin in critically ill patients

Overview of attention for article published in Annals of Intensive Care, May 2011
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

Mentioned by

news
3 news outlets
policy
1 policy source
twitter
1 X user
facebook
2 Facebook pages
wikipedia
5 Wikipedia pages

Citations

dimensions_citation
196 Dimensions

Readers on

mendeley
220 Mendeley
Title
Renal and neurological side effects of colistin in critically ill patients
Published in
Annals of Intensive Care, May 2011
DOI 10.1186/2110-5820-1-14
Pubmed ID
Authors

Herbert Spapen, Rita Jacobs, Viola Van Gorp, Joris Troubleyn, Patrick M Honoré

Abstract

Colistin is a complex polypeptide antibiotic composed mainly of colistin A and B. It was abandoned from clinical use in the 1970s because of significant renal and, to a lesser extent, neurological toxicity. Actually, colistin is increasingly put forward as salvage or even first-line treatment for severe multidrug-resistant, Gram-negative bacterial infections, particularly in the intensive care setting. We reviewed the most recent literature on colistin treatment, focusing on efficacy and toxicity issues. The method used for literature search was based on a PubMed retrieval using very precise criteria.Despite large variations in dose and duration, colistin treatment produces relatively high clinical cure rates. Colistin is potentially nephrotoxic but currently used criteria tend to overestimate the incidence of kidney injury. Nephrotoxicity independently predicts fewer cures of infection and increased mortality. Total cumulative colistin dose is associated with kidney damage, suggesting that shortening of treatment duration could decrease the incidence of nephrotoxicity. Factors that may enhance colistin nephrotoxicity (i.e., shock, hypoalbuminemia, concomitant use of potentially nephrotoxic drugs) must be combated or controlled. Neurotoxicity does not seem to be a major issue during colistin treatment. A better knowledge of colistin pharmacokinetics in critically ill patients is imperative for obtaining colistin dosing regimens that ensure maximal antibacterial activity at minimal toxicity.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 220 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Korea, Republic of 1 <1%
United States 1 <1%
Netherlands 1 <1%
Brazil 1 <1%
Unknown 216 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 29 13%
Student > Master 25 11%
Student > Ph. D. Student 24 11%
Researcher 22 10%
Other 14 6%
Other 48 22%
Unknown 58 26%
Readers by discipline Count As %
Medicine and Dentistry 60 27%
Pharmacology, Toxicology and Pharmaceutical Science 19 9%
Agricultural and Biological Sciences 17 8%
Biochemistry, Genetics and Molecular Biology 15 7%
Immunology and Microbiology 11 5%
Other 38 17%
Unknown 60 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 34. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2022.
All research outputs
#1,157,616
of 25,085,910 outputs
Outputs from Annals of Intensive Care
#135
of 1,169 outputs
Outputs of similar age
#4,412
of 117,456 outputs
Outputs of similar age from Annals of Intensive Care
#3
of 14 outputs
Altmetric has tracked 25,085,910 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,169 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.3. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 117,456 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.