| Title |
Probiotic mixture VSL#3 reduce high fat diet induced vascular inflammation and atherosclerosis in ApoE−/− mice
|
|---|---|
| Published in |
AMB Express, August 2016
|
| DOI | 10.1186/s13568-016-0229-5 |
| Pubmed ID | |
| Authors |
Yee Kwan Chan, Hani El-Nezami, Yan Chen, Kristiina Kinnunen, Pirkka V. Kirjavainen |
| Abstract |
Atherosclerosis results from chronic inflammation potentially caused by translocation of bacterial components from the oro-gastrointestinal tract to circulation. Specific probiotics have anti-inflammatory effects and may reduce bacterial translocation. We thereby tested whether a probiotic mixture with documented anti-inflammatory potential could reduce atherosclerosis. ApoE(-/-) mice were fed high fat diet alone or with VSL#3 or a positive control treatment, telmisartan or both for 12 weeks. All treatments reduced atherosclerotic plaques significantly compared to high fat diet alone. VSL#3 significantly reduced proinflammatory adhesion molecules and risk factors of plaque rupture, reduced vascular inflammation and atherosclerosis to a comparable extent to telmisartan; and VSL#3 treated mice had the most distinctly different intestinal microbiota composition from the control groups. Combining the VSL#3 and telmisartan brought no further benefits. Our findings showed the therapeutic potential of VSL#3 in reducing atherosclerosis and vascular inflammation. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 61 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 9 | 15% |
| Student > Master | 8 | 13% |
| Student > Ph. D. Student | 8 | 13% |
| Researcher | 6 | 10% |
| Other | 5 | 8% |
| Other | 2 | 3% |
| Unknown | 23 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 16% |
| Agricultural and Biological Sciences | 8 | 13% |
| Biochemistry, Genetics and Molecular Biology | 7 | 11% |
| Nursing and Health Professions | 5 | 8% |
| Immunology and Microbiology | 2 | 3% |
| Other | 4 | 7% |
| Unknown | 25 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 30. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 December 2016.
All research outputs
#1,117,890
of 22,884,315 outputs
Outputs from AMB Express
#11
of 1,236 outputs
Outputs of similar age
#22,435
of 336,882 outputs
Outputs of similar age from AMB Express
#1
of 53 outputs
Altmetric has tracked 22,884,315 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,236 research outputs from this source. They receive a mean Attention Score of 2.8. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.