| Title |
Perivascular mesenchymal stem cells in the adult human brain: a future target for neuroregeneration?
|
|---|---|
| Published in |
Clinical and Translational Medicine, November 2012
|
| DOI | 10.1186/2001-1326-1-30 |
| Pubmed ID | |
| Authors |
Ilknur Özen, Jordi Boix, Gesine Paul |
| Abstract |
Perivascular adult stem cells have been isolated from several tissues, including the adult human brain. They have unique signatures resembling both pericytes and mesenchymal stem cells. Understanding the nature of these cells in their specific vascular niches is important to determine their clinical potential as a new adult stem cell source. Indeed, they have promising features in vitro in terms of multipotency, immunomodulation and secretion of growth factors and cytokines. However, their in vivo function is less known as yet. Recent emerging data show a crucial role of perivascular mesenchymal stem cells in tissue homeostasis and repair. Furthermore, these cells may play an important role in adult stem cell niche regulation and in neurodegeneration. Here we review the recent literature on perivascular mesenchymal stem cells, discuss their different in vitro functions and highlight especially the specific properties of brain-derived perivascular mesenchymal stem cells. We summarize current evidence that suggests an important in vivo function of these cells in terms of their regenerative potential that may indicate a new target cell for endogenous tissue regeneration and repair. |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 2% |
| Italy | 1 | 2% |
| Unknown | 60 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 21% |
| Researcher | 13 | 21% |
| Student > Master | 7 | 11% |
| Student > Postgraduate | 5 | 8% |
| Student > Doctoral Student | 5 | 8% |
| Other | 10 | 16% |
| Unknown | 9 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 20 | 32% |
| Biochemistry, Genetics and Molecular Biology | 9 | 15% |
| Medicine and Dentistry | 8 | 13% |
| Neuroscience | 6 | 10% |
| Veterinary Science and Veterinary Medicine | 3 | 5% |
| Other | 3 | 5% |
| Unknown | 13 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2012.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from Clinical and Translational Medicine
#851
of 1,060 outputs
Outputs of similar age
#255,415
of 285,428 outputs
Outputs of similar age from Clinical and Translational Medicine
#5
of 7 outputs
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