Title |
Organoid: a powerful tool to study lung regeneration and disease
|
---|---|
Published in |
Cell Regeneration, April 2021
|
DOI | 10.1186/s13619-021-00082-8 |
Pubmed ID | |
Authors |
Tiantian Lu, Yiyuan Cao, Peng Zhao, Shengxi Shen, Ying Xi |
Abstract |
Organoids are three-dimensional self-organizing structures formed by adult tissue stem cells or pluripotent stem cells. They recapitulate cell-cell, cell-niche interactions in tissue development, homeostasis, regeneration and disease, and provide an in vitro model for drug screening. This review summarizes the recent advances of organoid cultures derived from adult lung stem cells and human pluripotent stem cells, especially focusing on the organoids of the distal airway stem/progenitor cells. We also discuss the applications of organoids in studying lung regeneration and pulmonary diseases, including pulmonary fibrosis, airway diseases and Coronavirus disease 2019 (COVID-19). |
X Demographics
Geographical breakdown
Country | Count | As % |
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China | 1 | 33% |
United States | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 69 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 17% |
Student > Master | 5 | 7% |
Student > Doctoral Student | 5 | 7% |
Student > Ph. D. Student | 5 | 7% |
Student > Bachelor | 4 | 6% |
Other | 8 | 12% |
Unknown | 30 | 43% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 16 | 23% |
Agricultural and Biological Sciences | 3 | 4% |
Immunology and Microbiology | 3 | 4% |
Unspecified | 2 | 3% |
Medicine and Dentistry | 2 | 3% |
Other | 13 | 19% |
Unknown | 30 | 43% |