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Stromal cells in tumor microenvironment and breast cancer

Overview of attention for article published in Cancer and Metastasis Reviews, November 2012
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (56th percentile)

Mentioned by

twitter
3 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
276 Dimensions

Readers on

mendeley
430 Mendeley
citeulike
2 CiteULike
Title
Stromal cells in tumor microenvironment and breast cancer
Published in
Cancer and Metastasis Reviews, November 2012
DOI 10.1007/s10555-012-9415-3
Pubmed ID
Authors

Yan Mao, Evan T. Keller, David H. Garfield, Kunwei Shen, Jianhua Wang

Abstract

Cancer is a systemic disease encompassing multiple components of both tumor cells themselves and host stromal cells. It is now clear that stromal cells in the tumor microenvironment play an important role in cancer development. Molecular events through which reactive stromal cells affect cancer cells can be defined so that biomarkers and therapeutic targets can be identified. Cancer-associated fibroblasts (CAFs) make up the bulk of cancer stroma and affect the tumor microenvironment such that they promote cancer initiation, angiogenesis, invasion, and metastasis. In breast cancer, CAFs not only promote tumor progression but also induce therapeutic resistance. Accordingly, targeting CAFs provides a novel way to control tumors with therapeutic resistance. This review summarizes the current understandings of tumor stroma in breast cancer with a particular emphasis on the role of CAFs and the therapeutic implications of CAFs. In addition, the effects of other stromal components such as endothelial cells, macrophages, and adipocytes in breast cancer are also discussed. Finally, we describe the biologic markers to categorize patients into a specific and confirmed subtype for personalized treatment.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 430 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 <1%
United States 2 <1%
Panama 1 <1%
Egypt 1 <1%
Denmark 1 <1%
France 1 <1%
Netherlands 1 <1%
Puerto Rico 1 <1%
Canada 1 <1%
Other 0 0%
Unknown 418 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 132 31%
Student > Bachelor 74 17%
Student > Master 63 15%
Researcher 59 14%
Student > Doctoral Student 28 7%
Other 74 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 141 33%
Biochemistry, Genetics and Molecular Biology 113 26%
Medicine and Dentistry 59 14%
Engineering 39 9%
Unspecified 28 7%
Other 50 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2017.
All research outputs
#6,939,526
of 12,336,133 outputs
Outputs from Cancer and Metastasis Reviews
#394
of 553 outputs
Outputs of similar age
#62,883
of 133,319 outputs
Outputs of similar age from Cancer and Metastasis Reviews
#7
of 16 outputs
Altmetric has tracked 12,336,133 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 553 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 133,319 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.