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PF-05231023, a long-acting FGF21 analogue, decreases body weight by reduction of food intake in non-human primates

Overview of attention for article published in Journal of Pharmacokinetics and Pharmacodynamics, July 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (53rd percentile)

Mentioned by

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2 tweeters
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1 Facebook page

Citations

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12 Dimensions

Readers on

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19 Mendeley
Title
PF-05231023, a long-acting FGF21 analogue, decreases body weight by reduction of food intake in non-human primates
Published in
Journal of Pharmacokinetics and Pharmacodynamics, July 2016
DOI 10.1007/s10928-016-9481-1
Pubmed ID
Authors

W. Clayton Thompson, Yingjiang Zhou, Saswata Talukdar, Cynthia J. Musante

Abstract

PF-05231023, a long-acting FGF21 analogue, is a promising potential pharmacotherapy for the treatment of obesity and associated comorbidities. Previous studies have shown the potential of FGF21 and FGF21-like compounds to decrease body weight in mice, non-human primates, and humans; the precise mechanisms of action remain unclear. In particular, there have been conflicting reports on the degree to which FGF21-induced weight loss in non-human primates is attributable to a decrease in food intake versus an increase in energy expenditure. Here, we present a semi-mechanistic mathematical model of energy balance and body composition developed from similar work in mice. This model links PF-05231023 administration and washout to changes in food intake, which in turn drives changes in body weight. The model is calibrated to and compared with recently published data from cynomolgus macaques treated with PF-05231023, demonstrating its accuracy in describing pharmacotherapy-induced weight loss in these animals. The results are consistent with the hypothesis that PF-05231023 decreases body weight in cynomolgus macaques solely by a reduction in food intake, with no direct effect on energy expenditure.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 5%
Unknown 18 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 26%
Student > Master 4 21%
Student > Bachelor 3 16%
Researcher 3 16%
Unspecified 2 11%
Other 2 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 37%
Biochemistry, Genetics and Molecular Biology 3 16%
Pharmacology, Toxicology and Pharmaceutical Science 2 11%
Unspecified 2 11%
Immunology and Microbiology 1 5%
Other 4 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 December 2016.
All research outputs
#7,042,863
of 12,323,473 outputs
Outputs from Journal of Pharmacokinetics and Pharmacodynamics
#65
of 149 outputs
Outputs of similar age
#122,974
of 266,192 outputs
Outputs of similar age from Journal of Pharmacokinetics and Pharmacodynamics
#1
of 4 outputs
Altmetric has tracked 12,323,473 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 149 research outputs from this source. They receive a mean Attention Score of 2.0. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,192 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them