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Proteins in DNA methylation and their role in neural stem cell proliferation and differentiation

Overview of attention for article published in Cell Regeneration, March 2021
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  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

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Title
Proteins in DNA methylation and their role in neural stem cell proliferation and differentiation
Published in
Cell Regeneration, March 2021
DOI 10.1186/s13619-020-00070-4
Pubmed ID
Authors

Jiaqi Sun, Junzheng Yang, Xiaoli Miao, Horace H. Loh, Duanqing Pei, Hui Zheng

Abstract

Epigenetic modifications, namely non-coding RNAs, DNA methylation, and histone modifications such as methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation play a significant role in brain development. DNA methyltransferases, methyl-CpG binding proteins, and ten-eleven translocation proteins facilitate the maintenance, interpretation, and removal of DNA methylation, respectively. Different forms of methylation, including 5-methylcytosine, 5-hydroxymethylcytosine, and other oxidized forms, have been detected by recently developed sequencing technologies. Emerging evidence suggests that the diversity of DNA methylation patterns in the brain plays a key role in fine-tuning and coordinating gene expression in the development, plasticity, and disorders of the mammalian central nervous system. Neural stem cells (NSCs), originating from the neuroepithelium, generate neurons and glial cells in the central nervous system and contribute to brain plasticity in the adult mammalian brain. Here, we summarized recent research in proteins responsible for the establishment, maintenance, interpretation, and removal of DNA methylation and those involved in the regulation of the proliferation and differentiation of NSCs. In addition, we discussed the interactions of chemicals with epigenetic pathways to regulate NSCs as well as the connections between proteins involved in DNA methylation and human diseases. Understanding the interplay between DNA methylation and NSCs in a broad biological context can facilitate the related studies and reduce potential misunderstanding.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 29%
Student > Master 4 14%
Researcher 2 7%
Student > Ph. D. Student 2 7%
Other 1 4%
Other 2 7%
Unknown 9 32%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 29%
Agricultural and Biological Sciences 3 11%
Medicine and Dentistry 3 11%
Neuroscience 2 7%
Psychology 1 4%
Other 1 4%
Unknown 10 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 June 2021.
All research outputs
#18,126,960
of 23,285,523 outputs
Outputs from Cell Regeneration
#105
of 159 outputs
Outputs of similar age
#299,441
of 419,786 outputs
Outputs of similar age from Cell Regeneration
#4
of 11 outputs
Altmetric has tracked 23,285,523 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 159 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 419,786 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.